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Extranodal NK/T cell lymphoma
- Source :
- Blood research
- Publication Year :
- 2019
- Publisher :
- Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis, 2019.
-
Abstract
- Extranodal natural killer (NK)/T cell lymphoma (ENKTL) is a distinct subtype of Non-Hodgkin's lymphoma mainly involving the nasal area. Since the entity was first recognized, treatment strategies have been evolving from anthracycline-based chemotherapy and radiotherapy to L-asparaginase containing regimens and recently immune checkpoint inhibitors. With the currently used combined chemotherapy and radiotherapy, more than 70% of patients with localized disease can be cured. L-asparaginase containing regimens have significantly improved treatment outcomes among patients with advanced disease. However, the treatment outcomes of patients with disease refractory to L-asparaginase containing regimens or who experience recurrence remain poor. In this article, we cover the current treatments for ENKTL and emerging treatment approaches.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
Extranodal natural killer/T cell lymphoma
Review Article
ENKTL
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
T-cell lymphoma
Chemotherapy
business.industry
Combination chemotherapy
Hematology
Immunotherapy
medicine.disease
Lymphoma
Non-Hodgkin's lymphoma
Radiation therapy
030220 oncology & carcinogenesis
Localized disease
Non-Hodgkin’s lymphoma
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 22880011 and 2287979X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Blood research
- Accession number :
- edsair.doi.dedup.....ce4ba5a588c771e3a0a1f2ea5b5a0228