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Synthesis and activity of a C-8 keto pleuromutilin derivative

Authors :
Laporte Thomas L
Margaret E. Sorenson
David B. Brzozowski
Timothy P. Connolly
Ronald L. Hanson
Stella Huang
Joanne J. Bronson
James A. Matson
Ramesh N. Patel
Dane M. Springer
Source :
Bioorganic & Medicinal Chemistry Letters. 13:1751-1753
Publication Year :
2003
Publisher :
Elsevier BV, 2003.

Abstract

A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.

Details

ISSN :
0960894X
Volume :
13
Database :
OpenAIRE
Journal :
Bioorganic & Medicinal Chemistry Letters
Accession number :
edsair.doi.dedup.....ce425399d33b6aa23dae5f78eb4ce770