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EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC, LEUKEMIA
- Source :
- Pediatric Hematology and Oncology. 26:48-56
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
- Subjects :
- Male
Adolescent
Bone Marrow
Biomarkers, Tumor
Humans
Medicine
PTEN
Child
Regulation of gene expression
Tissue microarray
biology
Gene Expression Regulation, Leukemic
business.industry
Protein Tyrosine Phosphatase, Non-Receptor Type 6
PTEN Phosphohydrolase
Infant
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Immunohistochemistry
Leukemia
medicine.anatomical_structure
Oncology
Tissue Array Analysis
Apoptosis
Case-Control Studies
Child, Preschool
Pediatrics, Perinatology and Child Health
biology.protein
Cancer research
Biomarker (medicine)
Female
Bone marrow
business
Subjects
Details
- ISSN :
- 15210669 and 08880018
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Pediatric Hematology and Oncology
- Accession number :
- edsair.doi.dedup.....ce2c9aff55d3f6aa45c0f97326f77bc8