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Serum levels of glial cell line-derived neurotrophic factor as a biomarker for mood disorders and lithium response
- Source :
- Psychiatry Research. 301:113967
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the pathophysiology of neuropsychiatric disorders. We examined serum GDNF levels in bipolar disorder (BD) patients and major depressive disorder (MDD) patients and their association with response to lithium therapy. We used a multicenter (six sites), exploratory, cross-sectional case-control design and recruited 448 subjects: 143 BD patients, 116 MDD patients, and 158 healthy controls (HCs). We evaluated the patients' clinical severity using the Clinical Global Impression (CGI), and responses to lithium therapy using the Alda scale. The serum GDNF levels were significantly decreased in the BD and MDD groups compared to the HCs, with no significant difference between the BD and MDD groups. After adjustment, the serum GDNF levels in the BD and MDD patients in remission or depressive states were decreased compared to the HC values. Lower serum GDNF levels in BD patients were associated with higher CGI and Alda scores (i.e., severe illness and good response to lithium therapy, respectively). Our findings suggest that the serum GDNF level may be a biomarker for both BD and MDD in remission or depressive states. The serum GDNF level may be associated with the lithium response of BD patients.
- Subjects :
- Oncology
medicine.medical_specialty
Lithium (medication)
Lithium
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Neurotrophic factors
Internal medicine
mental disorders
medicine
Glial cell line-derived neurotrophic factor
Humans
Glial Cell Line-Derived Neurotrophic Factor
Bipolar disorder
Biological Psychiatry
Depressive Disorder, Major
biology
Mood Disorders
urogenital system
business.industry
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Cross-Sectional Studies
nervous system
Mood disorders
biology.protein
Clinical Global Impression
Major depressive disorder
Biomarker (medicine)
business
Biomarkers
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 301
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research
- Accession number :
- edsair.doi.dedup.....ce2a9597de378e73b5fabb376dec9ccd