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Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression
- Source :
- Frontiers in Oncology, Vol 3 (2013), Frontiers in Oncology
- Publication Year :
- 2013
- Publisher :
- Frontiers Media SA, 2013.
-
Abstract
- The two most common primary bone malignancies, osteosarcoma and Ewing sarcoma, are both aggressive, highly metastatic cancers that most often strike teens, though both can be found in younger children and adults. Despite distinct origins and pathogenesis, both diseases share several mechanisms of progression and metastasis, including neovascularization, invasion, anoikis resistance, chemoresistance and evasion of the immune response. Some of these processes are well-studies in more common carcinoma models, and the observation from adult diseases may be readily applied to pediatric bone sarcomas. Neovascularization, which includes angiogenesis and vasculogenesis, is a clear example of a process that is likely to be similar between carcinomas and sarcomas, since the responding cells are the same in each case. Chemoresistance mechanisms also may be similar between other cancers and the bone sarcomas. Since osteosarcoma and Ewing sarcoma are mesenchymal in origin, the process of epithelial-to-mesenchymal transformation is largely absent in bone sarcomas, necessitating different approaches to study progression and metastasis in these diseases. One process that is less well-studied in bone sarcomas is dormancy, which allows micrometastatic disease to remain viable but not growing in distant sites – typically the lungs – for months or years before renewing growth to become overt metastatic disease. By understanding the basic biology of these processes, novel therapeutic strategies may be developed that could improve survival in children with osteosarcoma or Ewing sarcoma.
- Subjects :
- tumor dormancy
Cancer Research
Pathology
medicine.medical_specialty
Review Article
Disease
Bone Sarcoma
lcsh:RC254-282
Metastasis
Neovascularization
cancer signaling
medicine
metastasis
anoikis resistance
Osteosarcoma
intravasation
business.industry
Intravasation
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Primary bone
Oncology
Cancer research
Sarcoma
neovascularization
medicine.symptom
business
Ewing sarcoma
Subjects
Details
- ISSN :
- 2234943X
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....ce1fa35ba6e86b724e452c308c9d7a2c