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The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk
- Source :
- Oxidative medicine and cellular longevity (Online) 2019 (2019). doi:10.1155/2019/8061901, info:cnr-pdr/source/autori:Magenta A.; D'Agostino M.; Sileno S.; Di Vito L.; Uras C.; Abeni D.; Martino F.; Barilla F.; Madonna S.; Albanesi C.; Napolitano M.; Capogrossi M.C.; Melillo G./titolo:The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk/doi:10.1155%2F2019%2F8061901/rivista:Oxidative medicine and cellular longevity (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:2019, Oxidative Medicine and Cellular Longevity, Vol 2019 (2019), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2019
- Publisher :
- Landes Bioscience, Austin, TX , Stati Uniti d'America, 2019.
-
Abstract
- Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and a higher risk of cardiovascular (CV) events. We previously showed that the miR-200 family (miR-200s) is induced by ROS, miR-200c being the most upregulated member responsible for apoptosis, senescence, ROS increase, and nitric oxide decrease, finally causing endothelial dysfunction. Moreover, circulating miR-200c increases in familial hypercholesterolemic children and in plaques and plasma of atherosclerotic patients, two pathologies associated with increased ROS. Given miR-200s’ role in endothelial dysfunction, ROS, and inflammation, we hypothesized that miR-200s were modulated in lesional skin (LS) and plasma of psoriatic patients (Pso) and that their levels correlated with some CV risk determinants at a subclinical level. All Pso had severe psoriasis, i.e., Psoriasis Area and Severity Index PASI>10, and one of the following: at least two systemic psoriasis treatments, age at onset<40 years, and disease duration>10 years. RNA was extracted from plasma (Pso, N=29; Ctrl, N=29) and from nonlesional skin (NLS) and LS of 6 Pso and 6 healthy subject skin (HS) biopsies. miR-200 levels were assayed by quantitative RT-PCR. We found that all miR-200s were increased in LS vs. NLS and miR-200c was the most expressed and upregulated in LS vs. HS. In addition, circulating miR-200c and miR-200a were upregulated in Pso vs. Ctrl. Further, miR-200c positively correlated with PASI, disease duration, left ventricular (LV) mass, LV relative wall thickness (RWT), and E/e′, a marker of diastolic dysfunction. Multiple regression analysis indicates a direct association between miR-200c and both RWT and LV mass. Circulating miR-200a correlated positively only with LV mass and arterial pressure augmentation index, a measure of stiffness, although the correlations were nearly significant (P=0.06). In conclusion, miR-200c is upregulated in LS and plasma of Pso, suggesting its role in ROS increase and inflammation associated with CV risk in psoriasis.
- Subjects :
- Male
Risk
0301 basic medicine
Senescence
Aging
medicine.medical_specialty
Article Subject
Endothelium
Inflammation
030204 cardiovascular system & hematology
medicine.disease_cause
Severity of Illness Index
Biochemistry
03 medical and health sciences
0302 clinical medicine
Psoriasis Area and Severity Index
Psoriasis
Internal medicine
medicine
Humans
oxidative stress
lcsh:QH573-671
Endothelial dysfunction
Skin
microRNA
lcsh:Cytology
business.industry
Cell Biology
General Medicine
psoriasis
Middle Aged
medicine.disease
Up-Regulation
cardiovascular diseases
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Blood pressure
Endocrinology
Disease Progression
Female
Endothelium, Vascular
medicine.symptom
Reactive Oxygen Species
business
Biomarkers
Oxidative stress
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Oxidative medicine and cellular longevity (Online) 2019 (2019). doi:10.1155/2019/8061901, info:cnr-pdr/source/autori:Magenta A.; D'Agostino M.; Sileno S.; Di Vito L.; Uras C.; Abeni D.; Martino F.; Barilla F.; Madonna S.; Albanesi C.; Napolitano M.; Capogrossi M.C.; Melillo G./titolo:The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk/doi:10.1155%2F2019%2F8061901/rivista:Oxidative medicine and cellular longevity (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:2019, Oxidative Medicine and Cellular Longevity, Vol 2019 (2019), Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....ce17b098af66951ac7c713f7631327f7