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Early steroid withdrawal does not increase risk for recurrent focal segmental glomerulosclerosis
- Source :
- ResearcherID
-
Abstract
- Experience with early corticosteroid withdrawal (CSWD) in renal transplant recipients with focal segmental glomerulosclerosis (FSGS) has not been previously reported. Since corticosteroids are used to treat primary FSGS, concern exists as to whether early CSWD regimens will be associated with an increased risk of FSGS recurrence posttransplant. The purpose of the present study was to evaluate the results of early CSWD in FSGS recipients and compare these results to a historic control group of FSGS patients who underwent renal transplantation under corticosteroid-based immunosuppression. Methods Forty-three patients with FSGS underwent renal transplantation with early CSWD. Results in these patients were compared to FSGS patients that underwent renal transplantation with chronic corticosteroid therapy. All rejection episodes were biopsy proven with grading by Banff criteria. Statistical analyses included Student's t test and chi square tests. Results Results in 43 patients with a median follow-up of 569 days were analyzed and compared to control patients. There was no significant difference in recurrent FSGS, time to recurrence, or graft loss. Conclusion CSWD does not increase risk for recurrence of FSGS. These observations indicate that ECSW can be achieved in FSGS patients, thereby affording them the benefits of steroid elimination.
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
medicine.drug_class
medicine.medical_treatment
Urology
urologic and male genital diseases
Drug Administration Schedule
Steroid withdrawal
Primary FSGS
chemistry.chemical_compound
Focal segmental glomerulosclerosis
Adrenal Cortex Hormones
Recurrence
Risk Factors
Biopsy
Chi-square test
medicine
Humans
Treatment Failure
Risk factor
Kidney transplantation
Transplantation
Creatinine
medicine.diagnostic_test
Glomerulosclerosis, Focal Segmental
urogenital system
business.industry
Immunosuppression
Middle Aged
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
Surgery
chemistry
Corticosteroid
business
Follow-Up Studies
Kidney disease
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.doi.dedup.....ce16a79ed83f30c9f6a41112dc432221