Back to Search
Start Over
Interleukin-17A Interweaves the Skeletal and Immune Systems
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 11 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- The complex crosstalk between the immune and the skeletal systems plays an indispensable role in the maintenance of skeletal homeostasis. Various cytokines are involved, including interleukin (IL)-17A. A variety of immune and inflammatory cells produces IL-17A, especially Th17 cells, a subtype of CD4+ T cells. IL-17A orchestrates diverse inflammatory and immune processes. IL-17A induces direct and indirect effects on osteoclasts. The dual role of IL-17A on osteoclasts partly depends on its concentrations and interactions with other factors. Interestingly, IL-17A exerts a dual role in osteoblasts in vitro. IL-17A is a bone-destroying cytokine in numerous immune-mediated bone diseases including postmenopausal osteoporosis (PMOP), rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondylarthritis (axSpA). This review will summarize and discuss the pathophysiological roles of IL-17A on the skeletal system and its potential strategies for application in immune-mediated bone diseases.
- Subjects :
- lcsh:Immunologic diseases. Allergy
rheumatoid arthritis
0301 basic medicine
medicine.medical_treatment
Osteoimmunology
Immunology
Osteoclasts
Review
interleukin-17A
postmenopausal osteoporosis
Arthritis, Rheumatoid
03 medical and health sciences
Psoriatic arthritis
0302 clinical medicine
Immune system
Spondylarthritis
medicine
Humans
Immunology and Allergy
Osteoporosis, Postmenopausal
osteoimmunology
psoriatic arthritis
030203 arthritis & rheumatology
Osteoblasts
business.industry
Arthritis, Psoriatic
Interleukin-17
Interleukin
axial spondyloarthritis
medicine.disease
030104 developmental biology
Cytokine
Rheumatoid arthritis
Cytokines
Th17 Cells
Interleukin 17
lcsh:RC581-607
business
Homeostasis
Signal Transduction
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....ce1681648c7cb2870c8d0b9bf3e1ac89