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Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 6, p e0214563 (2019)
- Publication Year :
- 2019
-
Abstract
- BackgroundAfrica has the highest rates of child mortality. Little is known about outcomes after hospitalization for children with very severe anemia.ObjectiveTo determine one year mortality and predictors of mortality in Tanzanian children hospitalized with very severe anemia.MethodsWe conducted a prospective cohort study enrolling children 2-12 years hospitalized from August 2014 to November 2014 at two public hospitals in northwestern Tanzania. Children were screened for anemia and followed until 12 months after discharge. The primary outcome measured was mortality. Predictors of mortality were determined using Cox regression analysis.ResultsOf the 505 children, 90 (17.8%) had very severe anemia and 415 (82.1%) did not. Mortality was higher for children with very severe anemia compared to children without over a one year period from admission, 27/90 (30.0%) vs. 59/415 (14.2%) respectively (Hazard Ratio (HR) 2.42, 95% Cl 1.53–3.83). In-hospital mortality was 11/90 (12.2%) and post-hospital mortality was 16/79 (20.2%) for children with very severe anemia. The strongest predictors of mortality were age (HR 1.01, 95% Cl 1.00–1.03) and decreased urine output (HR 4.30, 95% Cl 1.04 – 17.7).ConclusionsChildren up to 12 years of age with very severe anemia have nearly a 30% chance of mortality following admission over a one year period, with over 50% of mortality occurring after discharge. Post-hospital interventions are urgently needed to reduce mortality in children with very severe anemia, and should include older children.
- Subjects :
- Male
Pediatrics
Psychological intervention
Tanzania
Biochemistry
Cohort Studies
Families
0302 clinical medicine
Risk Factors
Cause of Death
Prevalence
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Child
Children
Cause of death
Multidisciplinary
biology
Hazard ratio
Anemia
Hematology
3. Good health
Hospitalization
Genetic Diseases
Research Design
Child, Preschool
Medicine
Regression Analysis
Female
Research Article
medicine.medical_specialty
Death Rates
Science
030231 tropical medicine
Research and Analysis Methods
Severe anemia
One year mortality
03 medical and health sciences
Population Metrics
Autosomal Recessive Diseases
Diagnostic Medicine
medicine
Humans
Hemoglobin
Mortality
Clinical Genetics
Sickle Cell Disease
Population Biology
Proportional hazards model
business.industry
Biology and Life Sciences
Proteins
biology.organism_classification
medicine.disease
Child mortality
Hemoglobinopathies
Age Groups
People and Places
Population Groupings
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....ce10d1946849e0c79ffc42ba76a314dd