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Therapeutic efficacy of buforin II and rifampin in a rat model of Acinetobacter baumannii sepsis
- Source :
- Critical care medicine. 37(4)
- Publication Year :
- 2009
-
Abstract
- Objective To investigate the efficacy of buforin II and rifampin in an experimental rat model of Acinetobacter baumannii sepsis. Design Prospective, randomized, controlled animal study. Setting Research laboratory in a university hospital. Subjects Adult male Wistar rats. Interventions The animals received intraperitoneally 1 mL saline containing 2 x 10 colony forming units of A. baumannii ATCC 19606 (model i) or the multiresistant strain (model ii). Immediately after bacterial challenge, animals received intravenously a single dose of isotonic sodium chloride solution (control groups C1 and C2), 1 mg/kg of buforin II, 10 mg/kg of rifampin, and 1 mg/kg of buforin II plus 10 mg/kg of rifampin, respectively. Measurements and main results Lethality, bacterial growth in blood and tissue burden, endotoxin, interleukin-6, and tumor necrosis factor-alpha concentrations in plasma. Buforin II showed good antimicrobial activity and achieved a significant reduction of plasma endotoxin and cytokines concentration when compared with control and rifampin-treated groups. Combination among buforin II proved to be the most effective treatment in reducing all variables measured. Conclusion In an experimental model, buforin II and rifampin might have a potential role in the treatment of severe infections due to A. baumannii.
- Subjects :
- Acinetobacter baumannii
Male
medicine.drug_class
medicine.medical_treatment
Antibiotics
Critical Care and Intensive Care Medicine
Microbiology
Sepsis
Intensive care
medicine
Animals
Rats, Wistar
Saline
Antibiotics, Antitubercular
Antibacterial agent
Protein synthesis inhibitor
biology
business.industry
Proteins
medicine.disease
biology.organism_classification
Rats
Disease Models, Animal
Rifampin
business
Rifampicin
medicine.drug
Acinetobacter Infections
Subjects
Details
- ISSN :
- 15300293
- Volume :
- 37
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Critical care medicine
- Accession number :
- edsair.doi.dedup.....ce10700d8eaf575d04efbdc0dcf2fe6e