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Tea consumption and colorectal cancer risk: a meta-analysis of prospective cohort studies
- Source :
- European Journal of Nutrition. 59:3603-3615
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Data from in vitro and animal studies support the preventive effect of tea (Camellia sinensis) against colorectal cancer. Further, many epidemiologic studies evaluated the association between tea consumption and colorectal cancer risk, but the results were inconsistent. We conducted a meta-analysis of prospective cohort studies to systematically assess the association between tea consumption and colorectal cancer risk. A comprehensive literature review was conducted to identify the related articles by searching PubMed and Embase up to June, 2019. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a fixed effect model. Twenty cohort articles were included in the present meta-analysis involving 2,068,137 participants and 21,437 cases. The combined RR of colorectal cancer for the highest vs. lowest tea consumption was determined to 0.97 (95% CI 0.94–1.01) with marginal heterogeneity (I2 = 24.0%, P = 0.093) among all studies. This indicated that tea consumption had no significant association with colorectal cancer risk. Stratified analysis showed that no significant differences were found in all subgroups. We further conducted the gender-specific meta-analysis for deriving a more precise estimation. No significant association was observed between tea consumption and colorectal cancer risk in male (combined RR = 0.97; 95% CI 0.90–1.04). However, tea consumption had a marginal significant inverse impact on colorectal cancer risk in female (combined RR = 0.93; 95% CI 0.86–1.00). Further, we found a stronger inverse association between tea consumption and risk of colorectal cancer among the female studies with no adjustment of coffee intake (RR: 0.90; 95% CI 0.82–1.00, P 0.05). Our finding indicates that tea consumption has no significant impact on the colorectal cancer risk in both genders combined, but gender-specific meta-analysis shows that tea consumption has a marginal significant inverse impact on colorectal cancer risk in female.
- Subjects :
- Male
Risk
0301 basic medicine
Oncology
medicine.medical_specialty
Inverse Association
Colorectal cancer
Medicine (miscellaneous)
030209 endocrinology & metabolism
Coffee
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Prospective Studies
Tea consumption
Prospective cohort study
030109 nutrition & dietetics
Nutrition and Dietetics
Tea
business.industry
medicine.disease
Confidence interval
Relative risk
Meta-analysis
Cohort
Female
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 14366215 and 14366207
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- European Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....ce0ddf2d2d13dfb91e0e20d9df7b657a