Back to Search
Start Over
Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy
- Source :
- Technology in Cancer Research & Treatment, Vol 20 (2021), Technology in Cancer Research & Treatment
- Publication Year :
- 2021
- Publisher :
- SAGE Publishing, 2021.
-
Abstract
- Objectives: Hippocampus-sparing whole-brain radiotherapy (HS-WBRT) using tomotherapy is known to provide a better dose distribution than volumetric-modulated arc therapy but requires an extended irradiation time. The present study aimed to investigate whether irradiation time can be shortened by reducing the modulation factor (MF) without losing the target dose distribution. Methods: Using six tilted computed tomography images in the head area, the planning target volume (PTV) and hippocampal doses, and the irradiation time was investigated with a jaw width of 1 cm, a pitch of 0.200, and the MF changed from 3.0 to 2.6, 2.2, 1.8, and 1.4. Results: No significant changes in the PTV or hippocampus were found with MF in the range from 3.0 to 1.8, but marked deterioration was found with that of 1.4. The irradiation time showed a linear relationship with the MF within the range from 3.0 to 1.8, with 1334, 1158, 986, and 817 s at modulation factors of 3.0, 2.6, 2.2, and 1.8, respectively. However, when the MF was 1.4, the irradiation time was 808 s. Conclusions: When HS-WBRT is performed with a tilted body position and a jaw width of 1 cm, with a MF of 1.8, a favorable balance between dose parameters and irradiation time is achieved, whereas with a MF of 1.4, the quality of the radiotherapy plan deteriorates, and the irradiation time is approximately the same as that with a MF of 1.8.
- Subjects :
- tilt heading
Cancer Research
hippocampus-sparing
Time Factors
medicine.medical_treatment
tomotherapy
Hippocampus
Irradiation time
Dose distribution
Radiation Dosage
whole-brain radiotherapy
Patient Positioning
Tomotherapy
Treatment plan
brain metastases
Humans
Medicine
Radiation Injuries
RC254-282
Brain Neoplasms
business.industry
Radiotherapy Planning, Computer-Assisted
Whole brain radiotherapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Modulation factor
Radiation therapy
Oncology
Original Article
Radiotherapy, Intensity-Modulated
Cranial Irradiation
Tomography, X-Ray Computed
Nuclear medicine
business
Organ Sparing Treatments
Subjects
Details
- Language :
- English
- ISSN :
- 15330338
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Technology in Cancer Research & Treatment
- Accession number :
- edsair.doi.dedup.....ce07941303cc3cfab8ecaa0a1720048d