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Contribution of the central histaminergic transmission in the cataleptic and neuroleptic effects of haloperidol
- Source :
- Pharmacology Biochemistry and Behavior. 139:59-66
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- The antipsychotic properties of haloperidol are primarily attributed to its ability to block dopamine D2 receptors. Histaminergic transmission modulates some of the behavioral effects of haloperidol. Hence, the present study investigated the contribution of central histaminergic transmission in the cataleptic and neuroleptic effect of haloperidol respectively, using bar test and conditioned avoidance response (CAR) in a two-way shuttle box. The studies revealed that haloperidol (0.50 or 1 mg/kg, i.p.) exhibited cataleptic behavior and inhibited conditioned avoidance response (CAR) in the doses 0.25 or 0.50 mg in rats. The rats, pretreated centrally (i.c.v.) with histamine precursor, L-histidine (1, 2.5 μg) or histamine neuronal inducer (H3 receptor antagonist), thioperamide (20, 50 μg/rat), showed an enhanced cataleptic effect with sub-maximal dose of haloperidol (0.5 mg/kg, i.p.). Similarly, the neuroleptic effect of haloperidol (0.25 mg/kg, i.p.) in CAR was also potentiated in the rats pretreated with L-histidine (2.5 μg) or thioperamide (50 μg/rat). Further, the cataleptic effect of haloperidol (1 mg/kg, i.p.) was attenuated in rats pretreated with the H1 receptor antagonist, chlorpheniramine (60, 80 μg/rat, i.c.v.) or H2 receptor antagonist, ranitidine (60 μg/rat, i.c.v.). However, the neuroleptic effect of haloperidol (0.5 mg/kg, i.p.) was completely reversed by pretreatment with ranitidine (60 μg/rat, i.c.v.), and partially attenuated by chlorpheniramine (80 μg/rat, i.c.v.). These findings suggest the possible involvement of histaminergic transmission in the cataleptic and neuroleptic effects of haloperidol probably via H1 or H2 receptor stimulation.
- Subjects :
- Male
Chlorpheniramine
medicine.medical_specialty
Clinical Biochemistry
Pharmacology
Catalepsy
Ranitidine
Toxicology
Synaptic Transmission
Biochemistry
Histamine agonist
Histamine Agonists
Behavioral Neuroscience
chemistry.chemical_compound
Piperidines
Internal medicine
Dopamine receptor D2
Avoidance Learning
Haloperidol
medicine
Animals
Histidine
Biological Psychiatry
Thioperamide
Dose-Response Relationship, Drug
Chemistry
Antagonist
Histaminergic
Drug Synergism
medicine.disease
Rats
Infusions, Intraventricular
Endocrinology
Receptors, Histamine
H3 receptor antagonist
Antipsychotic Agents
Histamine
medicine.drug
Subjects
Details
- ISSN :
- 00913057
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....cdff55675aad9fc3058817da3d8398bb