Substantiation of the composition of surface-active substances in development of a cream with silver citrate

Pharmaceutical emulsions are now given increasing attention because they are widely used in medical practice. This became possible due to a qualitatively new level of scientific research and achievements in the field of emulsion systems creation, as well as expansion of assortment of auxiliary substances and use of new modern equipment. Emulsions are heterogeneous disperse systems that are potentially unstable. Therefore, the issue of stabilizing of emulsion systems is the main problem in area of emulsions technology. Aim. The aim of the experiment was to study structural and mechanical properties of concentrated emulsion systems, depending on the total concentration of surfactants, as well as investigation of colloidal and thermal stability of samples for substantiation of the composition of surfactants in the development of a cream with silver citrate. Methods. Pharmaco-technological methods of research were conducted in accordance with the requirements of the State Pharmacopoeia of Ukraine. Research results. Colloidal and thermal stability of the samples of emulsion cream with silver citrate was investigated. It has been established that the use of emulsifiers in concentrations of 4 % and 6 % does not provide physical stability. A dispersion analysis of the heterogeneous systems was carried out, which has shown that the samples obtained by using of the emulsifiers combination are homogeneous in size of particles of oil phase, which do not exceed 10 microns. The behavior of samples of the emulsion cream with silver citrate during and after mechanical destruction is investigated. The results guarantee stability of the system under the influence of mechanical processing during industrial production and use. Conclusion. As a result of the experiment, the use of the combination of surface-active substances: emulsifier № 1 and cetostearyl alcohol of 8-10 % was used to stabilize the emulsion system with silver citrate