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Potential targets for preclinical diagnostics of acute kidney injury in covid-19 patients (review of literature)
- Source :
- Russian Clinical Laboratory Diagnostics. 66:586-592
- Publication Year :
- 2021
- Publisher :
- EKOlab, 2021.
-
Abstract
- An relevance of the topic was defined by the high occurrence, unfavorable prognosis, lack of diagnostic techniques for early stages of acute kidney injury (AKI) disclosed in patients with COVID-19 (Coronavirus Disease 2019). Screening of medical literature for selection of AKI preclinical biomarkers was considered as main aim of this review. More than 200 publications from Russian Science Citation Index (RSCI), Scopus, The Cochrane Library, and MEDLINE were reviewed. Such risk factors as hypoxemia, increased intrathoracic pressure associated with Acute Respiratory Distress Syndrome (ARDS), hypertension (HT) involving endothelial dysfunction, and Diabetes mellitus were considered to be associated with AKI. There were explicated cytopathic and immune-mediated (cytokine-induced) mechanisms of COVID-19 associated AKI pathogenesis. Multiple methodological approaches were defined for detection and identification of the biomarkers based on urine proteome and metabolome screening. Perspective ways in the preclinical diagnostics of AKI such as detection of the markers of injury of the hypoxia-sensitive proximal canaliculi and the ATP metabolites that reflect first stages of the energy metabolism disorder in the epithelium lining canaliculi were identified in this study. The instantaneous and non-invasive investigation of different markers was regarded as possible method of the prognostication. The accuracy of the diagnosis on the initial stages of AKI, substantiate for preventive start of therapy, and make projections on the disease`s outcome will be improved due to the identification of high-sensitive specific biomarkers.
- Subjects :
- ARDS
SARS-CoV-2
business.industry
Biochemistry (medical)
Acute kidney injury
MEDLINE
COVID-19
General Medicine
Acute Kidney Injury
Cochrane Library
Prognosis
medicine.disease
Bioinformatics
Hypoxemia
Medical Laboratory Technology
Diabetes mellitus
medicine
Metabolome
Humans
medicine.symptom
Endothelial dysfunction
business
Biomarkers
Subjects
Details
- ISSN :
- 24121320 and 08692084
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Russian Clinical Laboratory Diagnostics
- Accession number :
- edsair.doi.dedup.....cdd5f6bbda9ec26290fd7136d8f1fa6a