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A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes
- Source :
- Archives of Virology. 156:1345-1358
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.
- Subjects :
- endocrine system
medicine.medical_specialty
Genotype
BOAR
viruses
Sus scrofa
Antibodies, Viral
Nationwide survey
medicine.disease_cause
Medical microbiology
Japan
Wild boar
Hepatitis E virus
Virology
biology.animal
Prevalence
medicine
Animals
Humans
Phylogeny
Disease Reservoirs
biology
urogenital system
virus diseases
General Medicine
digestive system diseases
Hepatitis E
Liver
RNA, Viral
Viral disease
Acute hepatitis
Subjects
Details
- ISSN :
- 14328798 and 03048608
- Volume :
- 156
- Database :
- OpenAIRE
- Journal :
- Archives of Virology
- Accession number :
- edsair.doi.dedup.....cdc9b875b1b179caec297d1d888aa4ac