Back to Search
Start Over
Oscillatory bands, neuronal synchrony and hippocampal function: Implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation
- Source :
- Brain Research. 1237:176-194
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands in 12 month-old male and female rats. Adult offspring of time-pregnant dams that were given a deficient level of choline (DEF=0.0 g/kg), sufficient choline (CON=1.1 g/kg) or supplemental choline (SUP=3.5 g/kg) in their chow during embryonic days (ED) 12-17 were implanted with an electroencephalograph (EEG) electrode in the hippocampal dentate gyrus in combination with an electromyograph (EMG) electrode patch implanted in the nuchal muscle. Five consecutive 8-h recording sessions revealed differential patterns of EEG activity as a function of awake, slow-wave sleep (SWS) and rapid-eye movement (REM) sleep states and prenatal choline status. The main finding was that SUP rats displayed increased power levels of gamma (30-100 Hz) band oscillations during all phases of the sleep/wake cycle. These findings are discussed within the context of a general review of neuronal oscillations (e.g., delta, theta, and gamma bands) and synchronization across multiple brain regions in relation to sleep-dependent memory consolidation in the hippocampus.
- Subjects :
- Male
Time Factors
Offspring
Hippocampus
Context (language use)
Hippocampal formation
Electroencephalography
Choline
chemistry.chemical_compound
Biological Clocks
Memory
Pregnancy
medicine
Animals
Prenatal Nutritional Physiological Phenomena
Molecular Biology
Nootropic Agents
medicine.diagnostic_test
Electromyography
General Neuroscience
Dentate gyrus
Rats
chemistry
Dietary Supplements
Female
Memory consolidation
Neurology (clinical)
Sleep
Psychology
Neuroscience
Algorithms
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1237
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....cdc8ef61569f60aa5541d42d857474a0