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Combining Phi6 as a surrogate virus and computational large‐eddy simulations to study airborne transmission of SARS‐CoV‐2 in a restaurant

Authors :
Lotta Oksanen
Mikko Auvinen
Joel Kuula
Rasmus Malmgren
Martin Romantschuk
Antti Hyvärinen
Sirpa Laitinen
Leena Maunula
Enni Sanmark
Ahmed Geneid
Svetlana Sofieva
Julija Salokas
Helin Veskiväli
Tarja Sironen
Tiia Grönholm
Antti Hellsten
Nina Atanasova
Ilmatieteen laitos
Finnish Meteorological Institute
Research Programs Unit
HUS Head and Neck Center
Korva-, nenä- ja kurkkutautien klinikka
Molecular and Integrative Biosciences Research Programme
Faculty of Biological and Environmental Sciences
Aerovirology Research Group
Helsinki Institute of Sustainability Science (HELSUS)
Biosciences
Ecosystems and Environment Research Programme
Departments of Faculty of Veterinary Medicine
Food Hygiene and Environmental Health
Helsinki One Health (HOH)
Food and Environmental Virology Research Group
Faculty of Medicine
Faculty Common Matters (Faculty of Medicine)
Viral Zoonosis Research Unit
Emerging Infections Research Group
Department of Virology
Faculty of Veterinary Medicine
Department of Microbiology
Publication Year :
2022
Publisher :
John Wiley & Sons A/S, 2022.

Abstract

COVID-19 has highlighted the need for indoor risk-reduction strategies. Our aim is to provide information about the virus dispersion and attempts to reduce the infection risk. Indoor transmission was studied simulating a dining situation in a restaurant. Aerosolized Phi6 viruses were detected with several methods. The aerosol dispersion was modeled by using the Large-Eddy Simulation (LES) technique. Three risk-reduction strategies were studied: (1) augmenting ventilation with air purifiers, (2) spatial partitioning with dividers, and (3) combination of 1 and 2. In all simulations infectious viruses were detected throughout the space proving the existence long-distance aerosol transmission indoors. Experimental cumulative virus numbers and LES dispersion results were qualitatively similar. The LES results were further utilized to derive the evolution of infection probability. Air purifiers augmenting the effective ventilation rate by 65% reduced the spatially averaged infection probability by 30%-32%. This relative reduction manifests with approximately 15 min lag as aerosol dispersion only gradually reaches the purifier units. Both viral findings and LES results confirm that spatial partitioning has a negligible effect on the mean infection-probability indoors, but may affect the local levels adversely. Exploitation of high-resolution LES jointly with microbiological measurements enables an informative interpretation of the experimental results and facilitates a more complete risk assessment.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....cdc47e5aa278a315b4b9f50866cf7c93