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High frequency of Panton-Valentine leukocidin genes in invasive methicillin-susceptible Staphylococcus aureus strains and the relationship with methicillin-resistant Staphylococcus aureus in Córdoba, Argentina
High frequency of Panton-Valentine leukocidin genes in invasive methicillin-susceptible Staphylococcus aureus strains and the relationship with methicillin-resistant Staphylococcus aureus in Córdoba, Argentina
- Source :
- European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 26(4)
- Publication Year :
- 2007
-
Abstract
- In the study presented here, the genetic characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) strains isolated from patients attending hospitals in the city of Cordoba, Argentina, during 1999-2002 were evaluated to determine their genetic relationship with methicillin-resistant S. aureus (MRSA) clones as part of an effort to control the potential emergence of new epidemic MRSA strains. The results showed there is a high frequency of MSSA strains carrying Panton-Valentine leukocidin genes in invasive infections in Cordoba, Argentina, particularly in those occurring in hospital settings. Panton-Valentine leukocidin genes were found in the genomic background of one clone (ST30-N pulsotype) belonging to a successful internationally distributed MSSA lineage (clonal complex 30), which is closely related to the EMRSA-16 pandemic clone. These genes were also detected in the ancestral clone (ST5-M pulsotype) of the most prevalent MRSA epidemic clone causing healthcare-associated infections in this region, known as the Cordobes/Chilean clone. The molecular characterization of circulating MSSA strains, including the detection of Panton-Valentine leukocidin genes, is thus a useful marker for investigating the evolving epidemiology of hospital- and community-acquired MRSA clones.
- Subjects :
- Microbiology (medical)
Adult
medicine.medical_specialty
Staphylococcus aureus
Adolescent
Gene Transfer, Horizontal
Bacterial Toxins
Clone (cell biology)
Leukocidin
Argentina
Exotoxins
Microbial Sensitivity Tests
Biology
medicine.disease_cause
Staphylococcal infections
Microbiology
Medical microbiology
Leukocidins
medicine
Humans
Child
Aged
Cross Infection
Infant
General Medicine
respiratory system
biochemical phenomena, metabolism, and nutrition
Middle Aged
Staphylococcal Infections
bacterial infections and mycoses
medicine.disease
Methicillin-resistant Staphylococcus aureus
Virology
Bacterial Typing Techniques
Electrophoresis, Gel, Pulsed-Field
Community-Acquired Infections
Infectious Diseases
Child, Preschool
bacteria
Methicillin Resistance
Panton–Valentine leukocidin
Methicillin Susceptible Staphylococcus Aureus
Subjects
Details
- ISSN :
- 09349723
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....cdbed18e32a75ca7dc4062589dba7bd8