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Performance of a histidine-rich protein 2 rapid diagnostic test, Paracheck Pf®, for detection of malaria infections in Ugandan pregnant women
- Publication Year :
- 2019
- Publisher :
- American Society of Tropical Medicine and Hygiene, 2019.
-
Abstract
- Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich protein 2–based rapid diagnostic tests (RDTs) for placental malaria infections in studies conducted at delivery. In this study, 81 women in Uganda in the second or third trimester of pregnancy were followed-up until delivery. At each visit, peripheral blood was tested by blood smear, RDT, and nested species-specific polymerase chain reaction (PCR). Sensitivity and specificity of the tests was calculated with PCR, which detected 22 infections of P. falciparum, as the gold standard. The sensitivity and specificity of blood smears were 36.4% (95% confidence interval [CI] = 18.0–59.2%) and 99.6% (95% CI = 97.7–100%), respectively. The corresponding values for RDT were 31.8% (95% CI = 14.7–54.9%) and 100% (95% CI = 98.3–100%). The RDTs could replace blood smears for diagnosis of malaria in pregnancy by virtue of their relative ease of use. Field-based sensitive tests for malaria in pregnancy are urgently needed.
- Subjects :
- medicine.medical_specialty
Plasmodium falciparum
Paracheck
Protozoan Proteins
Antigens, Protozoan
Polymerase Chain Reaction
Sensitivity and Specificity
Antimalarials
Species Specificity
Pregnancy
Virology
parasitic diseases
medicine
Humans
Uganda
Malaria, Falciparum
Quinine
Rapid diagnostic test
Fluorenes
biology
Obstetrics
Diagnostic Tests, Routine
Artemether, Lumefantrine Drug Combination
Gold standard (test)
Articles
biology.organism_classification
medicine.disease
Confidence interval
Artemisinins
Malaria
Diagnosis of malaria
Drug Combinations
Infectious Diseases
Treatment Outcome
diagnostic test
Ethanolamines
Pregnancy Complications, Parasitic
Immunology
Parasitology
Female
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....cdba07dde1228e8a86095f943038a198