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Efficacy of cyanoacrylate in the prevention of delayed bleeding after endoscopic mucosal resection of large colorectal polyps: a pilot study
- Source :
- International journal of colorectal disease. 35(11)
- Publication Year :
- 2020
-
Abstract
- Postoperative bleeding is a common complication after endoscopic polypectomy, particularly after endoscopic mucosal resection (EMR) of large non-pedunculated polyps, despite prophylactic clipping can reduce its occurrence. Cyanoacrylate glue has recently been proposed as a useful tool in reducing bleeding in surgery because of its adhesive and haemostatic properties. The aim of this study is to evaluate the usefulness of endoscopic application of a modified cyanoacrylate glue in the prevention of early or delayed post EMR bleeding. This is a pilot study. Inclusion criteria were patients between 18 and 75 years old affected by sessile or flat colonic polyps larger than 2 cm. Patients enrolled in the study were randomized in two groups: group A (EMR) and group B (EMR with the application of 0.3 ml of N-butyl-2-cyanoacrylate + methacryloxysulfolane—Glubran 2®). Fifteen patients in both group A and B were enrolled. There were no intraoperative complications but haemostatic clipping was necessary in 3 patients in each group because of active bleeding. Delayed (after 24 h) bleeding occurred in two patients (13.3%) in group A requiring hospital readmission and re-do endoscopy with apposition of haemostatic clips. No case of bleeding was recorded in group B (p = 0.48). The results of this pilot study suggest a potential role of local spray application of Glubran®2 in reducing post-procedural bleeding.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Endoscopic Mucosal Resection
medicine.medical_treatment
Colonic Polyps
Endoscopic mucosal resection
Pilot Projects
Postoperative Hemorrhage
Group B
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
law
Internal medicine
medicine
Humans
Cyanoacrylates
CLIPS
computer.programming_language
Aged
medicine.diagnostic_test
business.industry
Gastroenterology
Clipping (medicine)
Colonoscopy
Hepatology
Middle Aged
Surgery
Endoscopy
surgical procedures, operative
Cyanoacrylate
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Complication
computer
Subjects
Details
- ISSN :
- 14321262
- Volume :
- 35
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International journal of colorectal disease
- Accession number :
- edsair.doi.dedup.....cdb9765b7c98860d1c02c9f499623fb4