Back to Search
Start Over
Development and Validation of the Mucosal Inflammation Noninvasive Index For Pediatric Crohn’s Disease
- Source :
- Clinical Gastroenterology and Hepatology, 18(1), 133-+. W.B. Saunders
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background & Aims Mucosal healing (MH) has become a goal of therapy for Crohn’s disease (CD), but frequent endoscopies are not feasible. We aimed to develop and validate a non-invasive index to assess mucosal inflammation in children with CD. Methods We collected data from the multi-center prospective ImageKids study, in which children with CD underwent ileocolonoscopy with magnetic resonance enterography. We investigated the association of pediatric CD activity index (PCDAI) items and laboratory test results with the simple endoscopic score for CD (SESCD). We used these data in a blended mathematical judgmental clinimetric approach to develop a weighted categorized index to identify children with CD who have MH, which we called the MINI index. We validated the index using data from 3 independent patient cohorts. The derivation and validation cohorts included 154 and 168 children, respectively (age 14.1 ± 2.5 years and 14.2 ± 3.9 years), of whom 16% and 36% had MH (defined as SESCD Results In multivariable models, the stooling item of the PCDAI, erythrocyte sedimentation rate, and level of fecal calprotectin were associated with SESCD (all P Conclusions We developed an index to non-invasively assess mucosal inflammation in children with CD. This index, identifies children with MH with high sensitivity and specificity. The added benefit of MINI over measurement of fecal calprotectin was small but significant, especially for patients with concentrations of fecal calprotectin from 100 to 599 μg/g. ClinicalTrials.gov no: NCT01881490 .
- Subjects :
- medicine.medical_specialty
Crohn's disease
Hepatology
biology
Receiver operating characteristic
medicine.diagnostic_test
business.industry
C-reactive protein
Gastroenterology
Disease
medicine.disease
Inflammatory bowel disease
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Erythrocyte sedimentation rate
Internal medicine
biology.protein
medicine
030211 gastroenterology & hepatology
Calprotectin
business
Pediatric gastroenterology
Subjects
Details
- ISSN :
- 15423565
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Clinical Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....cdad24ba22b026ad2833f21cdc16a2cc