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Atrial fibrillation and autonomic nervous system: A translational approach to guide therapeutic goals
- Source :
- Journal of Arrhythmia, Vol 37, Iss 2, Pp 320-330 (2021), Journal of Arrhythmia
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The autonomic nervous system (ANS) is known to play an important role in the genesis and maintenance of atrial fibrillation (AF). Biomolecular and genetic mechanisms, anatomical knowledges with recent diagnostic techniques acquisitions, both invasive and non‐invasive, have enabled greater therapeutic goals in patients affected by AF related to ANS imbalance. Catheter ablation of ganglionated plexi (GP) in the left and right atrium has been proposed in varied clinical conditions. Moreover interesting results arise from renal sympathetic denervation and vagal nerve stimulation. Despite all this, in the scenario of ANS modulation translational strategies we necessary must consider the treatment or correction of dynamic factors such as obesity, obstructive sleep apnea, lifestyle, food, and stress. Finally, new antiarrhythmic drugs, gene therapy and “ablatogenomic” could be represent exciting future therapeutic perspectives.<br />Cardioneuroablation and cardioneuromodulation for patients affected by AF related to ANS imbalance.
- Subjects :
- Clinical Review
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Vagal nerve
medicine.medical_treatment
Catheter ablation
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
In patient
atrial fibrillation
030212 general & internal medicine
Atrium (heart)
business.industry
autonomic nervous system denervation
Atrial fibrillation
ganglionated plexi
medicine.disease
Obstructive sleep apnea
Autonomic nervous system
medicine.anatomical_structure
Renal sympathetic denervation
lcsh:RC666-701
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 18804276 and 18832148
- Volume :
- 37
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Arrhythmia
- Accession number :
- edsair.doi.dedup.....cda4a473e4b937d70a2010a96e1dd321