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Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort:A Factor Analysis
- Source :
- Dossus, L, Lukanova, A, Rinaldi, S, Allen, N, Cust, A E, Becker, S, Tjonneland, A, Hansen, L, Overvad, K, Chabbert-Buffet, N, Mesrine, S, Clavel-Chapelon, F, Teucher, B, Chang-Claude, J, Boeing, H, Drogan, D, Trichopoulou, A, Benetou, V, Bamia, C, Palli, D, Agnoli, C, Galasso, R, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, Peeters, P H M, Onland-Moret, N C, Redondo, M-L, Travier, N, Sanchez, M-J, Altzibar, J M, Chirlaque, M-D, Barricarte, A, Lundin, E, Khaw, K-T, Wareham, N, Fedirko, V, Romieu, I, Romaguera, D, Norat, T, Riboli, E & Kaaks, R 2013, ' Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort : A Factor Analysis ', American Journal of Epidemiology, vol. 177, no. 8, pp. 787-99 . https://doi.org/10.1093/aje/kws309, American Journal of Epidemiology 177 (2013) 8, American Journal of Epidemiology, 177(8), 787-799
- Publication Year :
- 2013
-
Abstract
- A "Western" lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992-2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled "insulin resistance/metabolic syndrome," "steroids," and "inflammation" factors. A fourth component, "lipids," was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis.
- Subjects :
- Blood Glucose
obesity
Nutrition and Disease
Epidemiology
postmenopausal women
adipose-tissue
Body Mass Index
Cohort Studies
growth-factor-i
0302 clinical medicine
Sex hormone-binding globulin
Risk Factors
Voeding en Ziekte
Germany
Prospective Studies
Prospective cohort study
0303 health sciences
biology
Incidence
pathogenesis
Middle Aged
3. Good health
European Prospective Investigation into Cancer and Nutrition
Postmenopause
C-Reactive Protein
Cholesterol
nutrition
030220 oncology & carcinogenesis
Female
Adiponectin
Waist Circumference
medicine.medical_specialty
medicine.drug_class
Risk Assessment
c-peptide
insulin-resistance
03 medical and health sciences
Insulin resistance
Somatomedins
Internal medicine
medicine
Humans
European Union
Life Style
Triglycerides
030304 developmental biology
VLAG
Aged
Inflammation
adiponectin
premenopausal
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Endometrial cancer
Estrogens
medicine.disease
Endometrial Neoplasms
Endocrinology
Premenopause
Estrogen
Case-Control Studies
biology.protein
Metabolic syndrome
business
Factor Analysis, Statistical
Biomarkers
Follow-Up Studies
Interleukin-1
Subjects
Details
- Language :
- English
- ISSN :
- 19922000 and 00029262
- Database :
- OpenAIRE
- Journal :
- Dossus, L, Lukanova, A, Rinaldi, S, Allen, N, Cust, A E, Becker, S, Tjonneland, A, Hansen, L, Overvad, K, Chabbert-Buffet, N, Mesrine, S, Clavel-Chapelon, F, Teucher, B, Chang-Claude, J, Boeing, H, Drogan, D, Trichopoulou, A, Benetou, V, Bamia, C, Palli, D, Agnoli, C, Galasso, R, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, Peeters, P H M, Onland-Moret, N C, Redondo, M-L, Travier, N, Sanchez, M-J, Altzibar, J M, Chirlaque, M-D, Barricarte, A, Lundin, E, Khaw, K-T, Wareham, N, Fedirko, V, Romieu, I, Romaguera, D, Norat, T, Riboli, E & Kaaks, R 2013, ' Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort : A Factor Analysis ', American Journal of Epidemiology, vol. 177, no. 8, pp. 787-99 . https://doi.org/10.1093/aje/kws309, American Journal of Epidemiology 177 (2013) 8, American Journal of Epidemiology, 177(8), 787-799
- Accession number :
- edsair.doi.dedup.....cd7d2d7f54fb04cdb7531d7ebbc06950