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A Formal Total Synthesis of Palmerolide A
- Source :
- Chemistry - A European Journal. 16:5858-5862
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- An efficient formal total synthesis of the marine natural product palmerolide A is reported herein, involving 24 longest linear steps. The key features of our synthesis involve a combination of Sharpless epoxidation and Shimizu reaction to construct the syn aldol moiety, a Julia–Kocienski reaction to construct the diene, and ring-closing metathesis to form the macrocycle.
- Subjects :
- Revised Structures
Sharpless epoxidation
Magnetic Resonance Spectroscopy
Organic-Synthesis
Diene
Stereochemistry
Medium-Sized Rings
Metathesis
Antineoplastic Agents
Ring-Closing Metathesis
Catalysis
chemistry.chemical_compound
Ring-closing metathesis
Aldol reaction
Moiety
Natural Products
B-Ring
Biological Products
Molecular Structure
Route
Organic Chemistry
Antitumor Agents
Total synthesis
Stereoisomerism
Marine Natural-Product
General Chemistry
A Synthesis
chemistry
Asymmetric Epoxidation
Olefin Metathesis
Julia-Kocienski Reaction
Organic synthesis
Macrolides
Structure Elucidation
Palladium
Subjects
Details
- ISSN :
- 09476539
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Chemistry - A European Journal
- Accession number :
- edsair.doi.dedup.....cd790915063ac024e0f9c0568ca40177