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Prognostic Value of Baseline Serum Lactate Dehydrogenase Level in Patients With Hairy Cell Leukemia
- Source :
- Clinical Lymphoma Myeloma and Leukemia. 20:e616-e621
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Hairy cell leukemia is a rare B-cell lymphoproliferative disorder. It has an indolent course with relapse and remission periods. The aim of this study was to investigate the clinical characteristics and risk factors affecting the outcome of patients with hairy cell leukemia. Patients and Methods The retrospective data of 65 patients were evaluated according to initial hematologic and biochemical parameters, response rates, progression-free survival, and overall survival. Factors effecting response and survival rates were analyzed. Results The median follow-up duration was 62.8 months (range, 5.7-229.3 months). The result of the analysis showed that the patients with relapse/progressive disease had higher lactate dehydrogenase (LDH) levels at the time of diagnosis than patients without relapse/progression (median [range], 243 [137-540] vs. 179 [99-334] U/L, P = .01). Patients with LDH ≥ 200.5 IU at the time of diagnosis were demonstrated to have a shorter progression-free survival than those with LDH Conclusion Serum LDH level is significantly associated with relapse/progression in hairy cell leukemia patients. Patients with higher LDH levels at diagnosis should be monitored closely even if they experience complete remission.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Purine analogue
Gastroenterology
Retrospective data
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Lactate dehydrogenase
medicine
Overall survival
Humans
In patient
Hairy cell leukemia
Aged
Retrospective Studies
Aged, 80 and over
Leukemia, Hairy Cell
L-Lactate Dehydrogenase
business.industry
Hematology
Middle Aged
Prognosis
medicine.disease
Survival Rate
Oncology
chemistry
030220 oncology & carcinogenesis
Female
business
Progressive disease
030215 immunology
Serum lactate dehydrogenase level
Subjects
Details
- ISSN :
- 21522650
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical Lymphoma Myeloma and Leukemia
- Accession number :
- edsair.doi.dedup.....cd74cb7bd70750b7d402e13a3931319f