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Jabuticaba (Myrciaria jaboticaba) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes
- Source :
- Molecules, Molecules, Vol 26, Iss 6697, p 6697 (2021), Volume 26, Issue 21
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The Brazilian berry scientifically known as jabuticaba is a fruit covered by a dark purple peel that is still rich in bioactives, especially polyphenols. Considering that, this work was aimed at obtaining an extract from the peel of jabuticaba fruits, identifying its main components, loading it in phospholipid vesicles specifically tailored for skin delivery and evaluating their biological efficacy. The extract was obtained by pressurized hot water extraction (PHWE), which is considered an easy and low dissipative method, and it was rich in polyphenolic compounds, especially flavonoids (ortho-diphenols and condensed tannins), anthocyanins (cyanidin 3-O-glucoside and delphinidin 3-O-glucoside) and gallic acid, which were responsible for the high antioxidant activity detected using different colorimetric methods (DPPH, FRAP, CUPRAC and metal chelation). To improve the stability and extract effectiveness, it was incorporated into ultradeformable phospholipid vesicles (transfersomes) that were modified by adding two different polymers (hydroxyethyl cellulose and sodium hyaluronate), thus obtaining HEcellulose-transfersomes and hyaluronan-transfersomes. Transfersomes without polymers were the smallest, as the addition of the polymer led to the formation of larger vesicles that were more stable in storage. The incorporation of the extract in the vesicles promoted their beneficial activities as they were capable, to a greater extent than the solution used as reference, of counteracting the toxic effect of hydrogen peroxide and even of speeding up the healing of a wound performed in a cell monolayer, especially when vesicles were enriched with polymers. Given that, polymer enriched vesicles may represent a good strategy to produce cosmetical and cosmeceutical products with beneficial properties for skin.
- Subjects :
- Keratinocytes
Antioxidant
DPPH
medicine.medical_treatment
Cyanidin
Pharmaceutical Science
Organic chemistry
Biocompatible Materials
wound healing
phenolic compounds
Antioxidants
Article
Analytical Chemistry
Anthocyanins
chemistry.chemical_compound
QD241-441
phospholipid vesicles
Drug Discovery
medicine
Humans
Gallic acid
Food science
Physical and Theoretical Chemistry
Phospholipids
reactive oxygen species
bioactives
Plant Extracts
Vesicle
circular economy
food and beverages
Hydrogen Peroxide
Hydrolyzable Tannins
Hot water extraction
Oxidative Stress
Proanthocyanidin
chemistry
Chemistry (miscellaneous)
Polyphenol
Fruit
Liposomes
Molecular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....cd6ce4ccfae3bfbd43dda290f8c8aa0f