Back to Search
Start Over
Modulation of T lymphocyte differentiation antigens: Influence of aging
- Source :
- Cellular Immunology. 77:395-401
- Publication Year :
- 1983
- Publisher :
- Elsevier BV, 1983.
-
Abstract
- In vitro modulation of human T lymphocyte surface differentiation antigens T3, T8, and T4, by their respective monoclonal antibodies, was studied as a function of donor age. Kinetic studies performed on lymphocytes from young adults indicated that modulation is dependent on concentration of antibody used and duration of culture. OKT3 modulates T3 rapidly (maximum at less than 24 hr) and relatively completely (79% at the highest concentration of antibody used). By 48 hr, regeneration of the T3 antigen is apparent. T8 modulation by OKT8 is slower (continued modulation at 48 hr) and less complete than is T3 modulation by OKT3. OKT4 does not modulate the T4 antigen. In elderly individuals modulation of T3 by OKT3 is preserved whereas modulation of T8 by OKT8 is significantly reduced (24 ± 8% at 48 hr vs 53 ± 4% for young controls). These observations document further age-related changes in properties of human T suppressor cells.
- Subjects :
- Adult
Antigens, Differentiation, T-Lymphocyte
Aging
T-Lymphocyte Differentiation Antigens
medicine.medical_specialty
medicine.drug_class
T-Lymphocytes
Immunology
chemical and pharmacologic phenomena
Antigen-Antibody Complex
Biology
Monoclonal antibody
Antigen
Internal medicine
medicine
Humans
Cells, Cultured
Aged
Regeneration (biology)
Antibodies, Monoclonal
T lymphocyte
In vitro
Endocrinology
Modulation
Antigens, Surface
biology.protein
Antibody
Subjects
Details
- ISSN :
- 00088749
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Cellular Immunology
- Accession number :
- edsair.doi.dedup.....cd6bdd1b08ab8c47b519ac2dd6eeadea