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Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats
- Source :
- European journal of drug metabolism and pharmacokinetics. 28(4)
- Publication Year :
- 2004
-
Abstract
- Effect of P-glycoprotein (P-gp) inhibitors erythromycin (Ery) and cyclosporin A(CsA) on brain pharmacokinetics of nimodipine (NMD) in rats was studied. NMD concentrations in rat plasma and brain were determined after iv 2 mg/kg NMD alone, co-administration with Ery and CsA, respectively. It was found that concentrations of NMD in plasma of the three groups had a little difference, but brain concentrations of NMD in rats co-administrated with Ery and CsA were significantly higher than those in rats NMD alone. Significances of NMD in rat brain were found at 20, 40, 60 and 90 min after iv NMD. The brain T(1/2) in rat treated with ery(75.0 min) and CsA(79.0 min) were larger than that (44.2 min) in rats NMD alone. The results indicated that P-gp inhibitors Ery and CsA may increase concentration in rat brain by inhibiting elimination of NMD from brain.
- Subjects :
- Male
medicine.medical_specialty
Pharmacology
Blood–brain barrier
Kidney
Pharmacokinetics
Cyclosporin a
Internal medicine
Testis
medicine
Animals
Pharmacology (medical)
Drug Interactions
ATP Binding Cassette Transporter, Subfamily B, Member 1
Enzyme Inhibitors
Nimodipine
Chromatography, High Pressure Liquid
P-glycoprotein
biology
business.industry
Kidney metabolism
Brain
Drug interaction
Ciclosporin
Calcium Channel Blockers
Anti-Bacterial Agents
Erythromycin
Rats
Endocrinology
medicine.anatomical_structure
Area Under Curve
biology.protein
Cyclosporine
business
medicine.drug
Half-Life
Subjects
Details
- ISSN :
- 03787966
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of drug metabolism and pharmacokinetics
- Accession number :
- edsair.doi.dedup.....cd6a8115b6f3ae4f77fe05b7558c833c