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Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS
- Source :
- eLife, Vol 8 (2019), eLife
- Publication Year :
- 2019
- Publisher :
- eLife Sciences Publications Ltd, 2019.
-
Abstract
- The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages, which are clusters of lineally related neurons. Neurons in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine, GABA, or glutamate) for communication. We generated a comprehensive neurotransmitter usage map for the entire ventral nerve cord. We did not find any cases of neurons using more than one neurotransmitter, but found that the acetylcholine specific gene ChAT is transcribed in many glutamatergic and GABAergic neurons, but these transcripts typically do not leave the nucleus and are not translated. Importantly, our work uncovered a simple rule: All neurons within a hemilineage use the same neurotransmitter. Thus, neurotransmitter identity is acquired at the stem cell level. Our detailed transmitter- usage/lineage identity map will be a great resource for studying the developmental basis of behavior and deciphering how neuronal circuits function to regulate behavior.
- Subjects :
- lineages
QH301-705.5
Science
Central nervous system
Biology
General Biochemistry, Genetics and Molecular Biology
neurotransmitters
chemistry.chemical_compound
Glutamatergic
ventral nerve cord
Neuroblast
medicine
Animals
Cell Lineage
Biology (General)
Neurotransmitter
Neurotransmitter Identity
Neurons
Neurotransmitter Agents
General Immunology and Microbiology
D. melanogaster
General Neuroscience
Stem Cells
fungi
Glutamate receptor
food and beverages
Cell Differentiation
General Medicine
central nervous system
stem cell
medicine.anatomical_structure
chemistry
nervous system
Ventral nerve cord
GABAergic
Medicine
Drosophila
Insight
Neuroscience
neuroblast
Acetylcholine
medicine.drug
Research Article
Developmental Biology
Subjects
Details
- Language :
- English
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....cd56f36a3379eaf4d5c2450f78022360