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The influence of age on valve disease in patients with varicose veins analysed by transmission electron microscopy and stereology
- Source :
- Vasa. 47:409-416
- Publication Year :
- 2018
- Publisher :
- Hogrefe Publishing Group, 2018.
-
Abstract
- Abstract. Background: The aim of this study was to investigate the influence of age on the ultrastructure of venous valve morphology in patients with C2 classified chronic venous disorders according to the CEAP classification. Patients and methods: The study population consisted of 16 consecutive patients with varicose veins (C2). The mean age was 49.8 years (30–66). The (pre-) terminal valve including the vessel wall was harvested within the proximal 2 centimetres of the great saphenous vein. The mean thickness (volume-to-surface ratio = V/S ratio) of elastin, collagen, endothelium and of the entire valve was determined. A blinded morphologist performed the examination by transmission electron microscopy and stereology. Analyses by Pearson’s product moment correlation, Kendall’s tau and Spearman’s rank correlation were performed to investigate whether there is a correlation between age and the ultrastructural morphology. Results: Stereological analysis of the valves demonstrated a mean V/S ratio (signifying a thickness estimation) for elastin of 0.87 μm3/μm2, for collagen of 18.0 μm3/μm2, for endothelium of 0.65 μm3/μm2, and for the entire valve of 25.2 μm³/μm². Statistical analyses showed no statistically significant correlation between age and the ultrastructural morphology in this patient group. Conclusions: The ultrastructural morphology of the venous valves in chronic venous disorders may not depend on age in patients presenting with C2 disease. This conclusion may or may not apply to all C classes as we investigated a homogenous group of patients with C2 limbs.
- Subjects :
- Pathology
medicine.medical_specialty
Biopsy
Stereology
030204 cardiovascular system & hematology
030230 surgery
Varicose Veins
03 medical and health sciences
0302 clinical medicine
Microscopy, Electron, Transmission
Predictive Value of Tests
Microscopy
Varicose veins
Humans
Medicine
Saphenous Vein
In patient
business.industry
Age Factors
Middle Aged
Transmission electron microscopy
Chronic Disease
Ultrastructure
Venous valve
Venous Valves
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Valve disease
Subjects
Details
- ISSN :
- 16642872 and 03011526
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Vasa
- Accession number :
- edsair.doi.dedup.....cd532201830d84a849d6b8109609816b