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Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer
- Source :
- Journal of Gastric Cancer
- Publication Year :
- 2015
-
Abstract
- PURPOSE Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients. MATERIALS AND METHODS Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009. RESULTS In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P
- Subjects :
- 0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Survival
Stomach neoplasms
Perineural invasion
medicine.disease_cause
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Tissue array analysis
Gastric mucosa
Medicine
Enhancer
Tissue microarray
business.industry
Cancer
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Lymphatic system
Oncology
TLE1
030220 oncology & carcinogenesis
Immunohistochemistry
Original Article
business
Carcinogenesis
Subjects
Details
- ISSN :
- 2093582X
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of gastric cancer
- Accession number :
- edsair.doi.dedup.....cd50ab5e54915f4fb4a6d16c497ad21b