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Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability
- Source :
- Nature Genetics, 50(5), 652-+. Nature Publishing Group, Hysi, P, Valdes, A M, Liu, F, Furlotte, N A, Evans, D M, Bataille, V, Visconti, A, Hemani, G, McMahon, G, Ring, S M, Smith, G D, Duffy, D L, Zhu, G, Gordon, S D, Medland, S E, Danae Lin, B, Willemsen, G, Hottenga, J-J, Vuckovic, D, Girotto, G, Gandin, I, Sala, C, Brumat, M, Gasparini, P, Daniela, T, Cocca, M, Robino, A, Yazar, S, Hewitt, A W, Chen, Y, Zeng, C, Uitterlinden, A G, Ikram, M A, Hamer, M A, van Duijn, C M, Nijsten, T E C, Mackey, D A, Falchi, M, Boomsma, D I, Martin, N G, Hinds, D A, Kayser, M & Spector, T 2018, ' Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability ', Nature Genetics, vol. 50, no. 5, pp. 652-656 . https://doi.org/10.1038/s41588-018-0100-5, Nature genetics, Nature Genetics, 50(5), 652-656. Nature Publishing Group, Hysi, P G, Valdes, A M, Liu, F, Furlotte, N A, Evans, D M, Bataille, V, Visconti, A, Hemani, G, McMahon, G, Ring, S M, Smith, G D, Duffy, D L, Zhu, G, Gordon, S D, Medland, S E, Lin, B D, Willemsen, G, Hottenga, J J, Vuckovic, D, Girotto, G, Gandin, I, Sala, C, Concas, M P, Brumat, M, Gasparini, P, Toniolo, D, Cocca, M, Robino, A, Yazar, S, Hewitt, A W, Chen, Y, Zeng, C, Uitterlinden, A G, Ikram, M A, Hamer, M A, Van Duijn, C M, Nijsten, T, MacKey, D A, Falchi, M, Boomsma, D I, Martin, N G, Hinds, D A, Kayser, M & Spector, T D 2018, ' Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability ', Nature Genetics, vol. 50, no. 5, pp. 652-656 . https://doi.org/10.1038/s41588-018-0100-5
- Publication Year :
- 2018
-
Abstract
- Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but 13 are novel. Collectively, single-nucleotide polymorphisms associated with hair color within these loci explain 34.6% of red hair, 24.8% of blond hair, and 26.1% of black hair heritability in the study populations. These results confirm the polygenic nature of complex phenotypes and improve our understanding of melanin pigment metabolism in humans.
- Subjects :
- 0301 basic medicine
Male
Netherlands Twin Register (NTR)
Multifactorial Inheritance
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Article
White People
03 medical and health sciences
0302 clinical medicine
Black hair
Genetic variation
Genotype
Genetics
Eye color
otorhinolaryngologic diseases
Journal Article
Humans
Hair Color
Aged
Chromosomes, Human, X
Autosome
integumentary system
Heritability
Middle Aged
030104 developmental biology
Phenotype
Evolutionary biology
Genetic Loci
Female
sense organs
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 50
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....cd467c2e84ae117002b39e8d6f9dbbad