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Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat
- Source :
- Agents and Actions. 30:393-402
- Publication Year :
- 1990
- Publisher :
- Springer Science and Business Media LLC, 1990.
-
Abstract
- The efficacy of various drugs used to treat ulcerative colitis, (sulfasalazine, 5-aminosalicylate, hydrocortisone) was investigated in a model of acetic acid-induced colitis in the rat. Subsequently, we tested the ability of antioxidant/5-lipoxygenase inhibitors (gossypol and nordihydroguiaretic acid [NDGA]) and a cyclooxygenase inhibitor (indomethacin) to attenuate the macroscopic colonic damage and/or neutrophil influx (myeloperoxidase activity [MPO]) associated with this model of colitis. Oral pretreatment with either sulfasalazine, gossypol, or NDGA significantly decreased colonic MPO activity induced by acetic acid. Intrarectal administration of such drugs resulted in an even larger reduction of the colonic inflammation, with gossypol being the most potent compound. Oral or intrarectal administration of corticosteroids (dexamethasone, hydrocortisone) also attenuated the parameters of acetic acid induced colitis. In contrast, pretreatment with indomethacin was ineffective, or when administered daily after colitis induction, indomethacin actually increased colonic neutrophil influx significantly. Our data suggest that both the route of drug administration and dosing regimen employed affect the antiinflammatory potency and/or efficacy of compounds on colitis induced by acetic acid in the rat. Drugs which were effective against this colitis may act by scavenging of oxygen derived free radicals.
- Subjects :
- Male
Antioxidant
Hydrocortisone
Neutrophils
medicine.medical_treatment
Indomethacin
Immunology
Anti-Inflammatory Agents
Acetates
Pharmacology
Toxicology
Dexamethasone
Leukocyte Count
chemistry.chemical_compound
Acetic acid
Sulfasalazine
medicine
Animals
Masoprocol
Pharmacology (medical)
Intestinal Mucosa
Colitis
Mesalamine
Acetic Acid
Peroxidase
biology
Gossypol
Rats, Inbred Strains
medicine.disease
Ulcerative colitis
Rats
Aminosalicylic Acids
Disease Models, Animal
chemistry
biology.protein
Colitis, Ulcerative
Cyclooxygenase
medicine.drug
Subjects
Details
- ISSN :
- 1420908X and 00654299
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Agents and Actions
- Accession number :
- edsair.doi.dedup.....cd426584292a8baf0de9e292f903b9a8