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In-vivo imaging of inner retinal cellular morphology with adaptive optics - Optical coherence tomography: Challenges and possible solutions
- Source :
- Zawadzki, RJ; Jones, SM; Kim, DY; Poyneer, L; Capps, AG; Hamann, B; et al.(2012). In-vivo imaging of inner retinal cellular morphology with adaptive optics-optical coherence tomography: challenges and possible solutions. OPHTHALMIC TECHNOLOGIES XXII, 8209. doi: 10.1117/12.907678. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/50h7v4gz
- Publication Year :
- 2012
- Publisher :
- eScholarship, University of California, 2012.
-
Abstract
- Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the outer layers of the human retina. Despite the significant progress in imaging cone and rod photoreceptor mosaics, visualization of cellular structures in the inner retina has been achieved only with extrinsic contrast agents that have not been approved for use with humans. In this paper we describe the main limiting factors in visualizing inner retinal cells and the methods we implemented to reduce their effects on images acquired with AO-OCT. These include improving the system point spread function (AO performance), monitoring of motion artifacts (retinal motion tracking), and speckle pattern reduction (temporal and spatial averaging). Results of imaging inner retinal morphology and the improvement offered by the new UC Davis AOOCT system with spatio-temporal image averaging are presented. © 2012 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
- Subjects :
- Point spread function
genetic structures
Computer science
imaging systems
adaptive optics
aberration compensation
Speckle pattern
chemistry.chemical_compound
Optics
Match moving
Optical coherence tomography
medicine
Adaptive optics
medical optics instrumentation
Retina
optical coherence tomography
medicine.diagnostic_test
complex conjugate artifact
business.industry
Retinal
eye diseases
Scanning laser ophthalmoscopy
ophthalmology
medicine.anatomical_structure
chemistry
sense organs
business
Preclinical imaging
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Zawadzki, RJ; Jones, SM; Kim, DY; Poyneer, L; Capps, AG; Hamann, B; et al.(2012). In-vivo imaging of inner retinal cellular morphology with adaptive optics-optical coherence tomography: challenges and possible solutions. OPHTHALMIC TECHNOLOGIES XXII, 8209. doi: 10.1117/12.907678. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/50h7v4gz
- Accession number :
- edsair.doi.dedup.....cd3d68fab36484564234604e0149c08c