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Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment
- Source :
- Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 659-669 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Introduction We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment. Methods Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire. Results Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters. Discussion The SS-OCT–measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population.<br />Highlights • Inner retinal layer thickness was reduced in patients with mild cognitive impairment. • Macular ganglion cell layer complex was the most affected retinal layer. • Peripapillary retinal nerve fiber layer thickness was not significantly reduced. • Cognitive tests significantly correlated with macular parameters.
- Subjects :
- Retinal Imaging
medicine.medical_specialty
Ganglion cell layer
genetic structures
Optic nerve
Nerve fiber layer
lcsh:Geriatrics
lcsh:RC346-429
Retina
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Optical coherence tomography
Ophthalmology
medicine
Dementia
lcsh:Neurology. Diseases of the nervous system
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
business.industry
Swept‐source
Macula
Montreal Cognitive Assessment
Mild cognitive impairment
Retinal
Alzheimer's disease
medicine.disease
eye diseases
lcsh:RC952-954.6
Psychiatry and Mental health
medicine.anatomical_structure
Retinal nerve fiber layer
chemistry
Swept-source
Neurology (clinical)
sense organs
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 23528729
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
- Accession number :
- edsair.doi.dedup.....cd3c1939bf92377274c83e8880681091