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New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins
- Source :
- Journal of Inorganic Biochemistry. 103:381-388
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Mimetics of antioxidant enzymes such as superoxide dismutases (SOD) or catalases are reported as potential new drugs able to reduce oxidative stress damage. In particular, manganese(III) complexes of salen-type ligands have been studied as both SOD and catalase mimetics. In this paper, we report the synthesis of two novel conjugates of salen-type ligands with the beta-cyclodextrin, the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(salicylidene))]-beta-cyclodextrin and the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(3-methoxysalicylidene))]-beta-cyclodextrin, their spectroscopic characterization, and the synthesis and the characterization of their manganese(III) complexes. The SOD-like activity of the metal complexes was investigated by the indirect Fridovich method. The catalase like activity was tested using a Clark-type oxygen electrode. The peroxidase activity was tested using the ABTS (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay. The glycoconjugation of salen-manganese(III) complexes yields compounds with enhanced SOD activity. These complexes also show catalase and peroxidase activities higher than the simple salen complexes (EUK 113 and EUK 108).
- Subjects :
- Antioxidant
Stereochemistry
medicine.medical_treatment
chemistry.chemical_element
manganese complexes
Manganese
medicine.disease_cause
Biochemistry
Inorganic Chemistry
Superoxide dismutase
chemistry.chemical_compound
cyclodextrins
salen
Biomimetic Materials
medicine
Peroxidase
chemistry.chemical_classification
ABTS
biology
Superoxide Dismutase
beta-Cyclodextrins
Catalase
Oxidative Stress
Enzyme
chemistry
biology.protein
Copper
Oxidative stress
Subjects
Details
- ISSN :
- 01620134
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Journal of Inorganic Biochemistry
- Accession number :
- edsair.doi.dedup.....cd3719fe741335392d77c269183370ae