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Crimean-Congo hemorrhagic fever: experience at a tertiary care hospital in Karachi, Pakistan
- Source :
- Transactions of the Royal Society of Tropical Medicine and Hygiene. 99(8)
- Publication Year :
- 2004
-
Abstract
- Crimean-Congo hemorrhagic fever (CCHF) is endemic in certain rural areas of Pakistan. Since the discovery of CCHF virus (CCHFV) in the country in the 1960s, there have been 13 outbreaks in addition to sporadic cases. An outbreak during 2000 coincided with the movement of sacrificial animals from rural to urban areas for the festival of Eid-ul-Azha. Diagnosis was suspected in patients with fever and thrombocytopenia, and confirmed retrospectively using immunoassays and reverse transcriptase-PCR. Patients were given platelet, plasma and red cell infusions. Management varied due to unfamiliarity with the condition and its treatment, lack of availability of diagnostic laboratory tests and limited supply of ribavirin. Inadequate antiviral treatment and late presentation probably contributed to the death of six of the eight patients. Renal failure, disseminated intravascular coagulation and persistent high-grade fever were associated with mortality. The nucleotide sequence of the small genomic RNA segment of the CCHFV isolated in this outbreak was found to be very closely related to the CCHFV strains previously isolated in Pakistan.
- Subjects :
- Crimean–Congo hemorrhagic fever
Adult
Male
medicine.medical_specialty
Adolescent
Biology
Body Temperature
Disease Outbreaks
chemistry.chemical_compound
Internal medicine
medicine
Humans
Pakistan
Diagnostic laboratory
Phylogeny
Disseminated intravascular coagulation
Reverse Transcriptase Polymerase Chain Reaction
Ribavirin
Public Health, Environmental and Occupational Health
Outbreak
General Medicine
Tertiary care hospital
Middle Aged
medicine.disease
Virology
Hematologic Diseases
Blood Cell Count
Infectious Diseases
chemistry
Tropical medicine
Hemorrhagic Fever Virus, Crimean-Congo
RNA, Viral
Parasitology
Hemorrhagic Fever, Crimean
Viral disease
Subjects
Details
- ISSN :
- 00359203
- Volume :
- 99
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....cd33dddb5d7b2b4a27c0cb45cf2dd6d0