Back to Search
Start Over
Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection
- Source :
- British Journal of Haematology
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Summary The inflammatory response to SARS/CoV‐2 (COVID‐19) infection may contribute to the risk of thromboembolic complications. α‐Defensins, antimicrobial peptides released from activated neutrophils, are anti‐fibrinolytic and prothrombotic in vitro and in mouse models. In this prospective study of 176 patients with COVID‐19 infection, we found that plasma levels of α‐defensins were elevated, tracked with disease progression/mortality or resolution and with plasma levels of interleukin‐6 (IL‐6) and D‐dimers. Immunohistochemistry revealed intense deposition of α‐defensins in lung vasculature and thrombi. IL‐6 stimulated the release of α‐defensins from neutrophils, thereby accelerating coagulation and inhibiting fibrinolysis in human blood, imitating the coagulation pattern in COVID‐19 patients. The procoagulant effect of IL‐6 was inhibited by colchicine, which blocks neutrophil degranulation. These studies describe a link between inflammation and the risk of thromboembolism, and they identify a potential new approach to mitigate this risk in patients with COVID‐19 and potentially in other inflammatory prothrombotic conditions.
- Subjects :
- Male
Neutrophils
medicine.medical_treatment
Severity of Illness Index
Mice
0302 clinical medicine
Risk Factors
Prospective Studies
biology
Hematology
Middle Aged
Thrombosis
Research Papers
Tubulin Modulators
Coagulation
COVID‐19 infection
030220 oncology & carcinogenesis
Models, Animal
Female
medicine.symptom
Research Paper
Adult
alpha-Defensins
Antimicrobial peptides
Inflammation
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
α‐defensins
Thromboembolism
Fibrinolysis
medicine
Animals
Humans
Risk factor
Interleukin 6
Blood Coagulation
thrombosis
Aged
business.industry
Interleukin-6
SARS-CoV-2
COVID-19
medicine.disease
interleukin‐6
Case-Control Studies
Immunology
biology.protein
Neutrophil degranulation
business
Colchicine
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 13652141 and 00071048
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....cd32ba9cd9e48a55b70a56524fe4d7ab