Back to Search
Start Over
Association between esophageal leiomyomatosis and p53 mutation
- Source :
- The Annals of thoracic surgery. 95(4)
- Publication Year :
- 2012
-
Abstract
- Li-Fraumeni syndrome is a cancer predisposition syndrome associated with a variety of neoplasms, mainly soft tissue sarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma, and leukemia. Esophageal leiomyomatosis involves the presence of several rare benign neoplastic lesions composed of proliferating smooth muscle cells in the esophageal wall. The current case report presents a patient with recurrent diffuse leiomyomas of the esophagus and confirmed p53 mutation with clinical criteria of Li-Fraumenilike syndrome.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Esophageal Neoplasms
Biopsy
DNA Mutational Analysis
P53 Mutation
Endoscopy, Gastrointestinal
Esophagus
Smooth muscle
Leiomyomatosis
medicine
Adrenocortical carcinoma
Humans
business.industry
Cancer predisposition
Soft tissue sarcoma
DNA, Neoplasm
Middle Aged
medicine.disease
Genes, p53
Esophageal leiomyomatosis
Leukemia
medicine.anatomical_structure
Mutation
Surgery
Female
Cardiology and Cardiovascular Medicine
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 15526259
- Volume :
- 95
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Annals of thoracic surgery
- Accession number :
- edsair.doi.dedup.....cd2f39f039339cdd271810c146ea0ef9