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Association between esophageal leiomyomatosis and p53 mutation

Authors :
Gil Bar-Sela
Ran Kremer
Jesse Lachter
Eugene Vlodavsky
Ludmilla Guralnik
Olga Kazarin
Source :
The Annals of thoracic surgery. 95(4)
Publication Year :
2012

Abstract

Li-Fraumeni syndrome is a cancer predisposition syndrome associated with a variety of neoplasms, mainly soft tissue sarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma, and leukemia. Esophageal leiomyomatosis involves the presence of several rare benign neoplastic lesions composed of proliferating smooth muscle cells in the esophageal wall. The current case report presents a patient with recurrent diffuse leiomyomas of the esophagus and confirmed p53 mutation with clinical criteria of Li-Fraumenilike syndrome.

Details

ISSN :
15526259
Volume :
95
Issue :
4
Database :
OpenAIRE
Journal :
The Annals of thoracic surgery
Accession number :
edsair.doi.dedup.....cd2f39f039339cdd271810c146ea0ef9