Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease

Authors :: Maria V. Grishchenko
Galina F. Makhaeva
Yanina V. Burgart
Elena V. Rudakova
Natalia P. Boltneva
Nadezhda V. Kovaleva
Olga G. Serebryakova
Sofya V. Lushchekina
Tatiana Y. Astakhova
Ekaterina F. Zhilina
Evgeny V. Shchegolkov
Rudy J. Richardson
Victor I. Saloutin
Source :: ChemMedChem. 17
Publication Year :: 2022
Publisher :: Wiley, 2022.
Abstract: New conjugates of tacrine and salicylamide with alkylene spacers were synthesized and evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC

Subjects :: Pharmacology
Amyloid beta-Peptides
Organic Chemistry
Biochemistry
Molecular Docking Simulation
Structure-Activity Relationship
Neuroprotective Agents
Alzheimer Disease
Butyrylcholinesterase
Salicylamides
Drug Discovery
Acetylcholinesterase
Tacrine
Humans
Molecular Medicine
Cholinesterase Inhibitors
General Pharmacology, Toxicology and Pharmaceutics

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