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Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
- Source :
- International Journal of Environmental Research and Public Health; Volume 19; Issue 11; Pages: 6921
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori (H. pylori) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti-H. pylori therapies in northeastern Poland. Patients and Methods: This was a retrospective, single-center study performed on 289 outpatients with an H. pylori infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. Results: BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti-H. pylori therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT—89.4% (84/94), (2) M-TT—80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT—84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. Conclusions: In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for H. pylori eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti-H. pylori therapy guidelines.
- Subjects :
- Helicobacter pylori
Metronidazole
Health, Toxicology and Mutagenesis
bismuth-containing quadruple therapy
eradication
levofloxacin-based triple therapy
metronidazole-based triple therapy
Poland
Public Health, Environmental and Occupational Health
Humans
Drug Therapy, Combination
Proton Pump Inhibitors
Bismuth
Anti-Bacterial Agents
Helicobacter Infections
Retrospective Studies
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....cd26ac3b86db4d7e39e4cd869cceae74
- Full Text :
- https://doi.org/10.3390/ijerph19116921