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Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction
- Source :
- Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 874-880 (2019), Beilstein Journal of Organic Chemistry
- Publication Year :
- 2019
- Publisher :
- Beilstein-Institut, 2019.
-
Abstract
- An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.
- Subjects :
- chemistry.chemical_classification
Reaction conditions
Base (chemistry)
Chemistry
Organic Chemistry
High selectivity
Combinatorial chemistry
Full Research Paper
lcsh:QD241-441
chemistry.chemical_compound
fused heterocyclic skeletons
Cascade reaction
chromane
lcsh:Organic chemistry
domino reaction
Atom economy
Chromane
lcsh:Q
lcsh:Science
pyrazolopyridines
Malononitrile
Subjects
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....cd245288c32aea941c2178835cd032f4