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Lack of association between TNF 238 G/A polymorphism and type 2 diabetes: a meta-analysis
- Source :
- Acta Diabetologica. 46:339-343
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- The aim of this meta-analysis was to determine the nature of the association between TNF 238 G/A polymorphism and the risk for T2D. We searched databases updated on January 2009 for all publications on the association between this variation and T2D. Data on genotypes and the numbers of cases and controls were assessed using Review Manager 4.2. Meta-analysis of the overall and specific populations was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed-effect model. I(2) statistic was calculated to examine heterogeneity, and publication bias was evaluated by Egger test. The overall OR (95% CI) for AA and GA genotypes versus GG genotype for TNF-alpha-238 was 1.15 (0.92-1.44), which in European and Asian populations were 1.18 (0.92-1.51) and 1.13 (0.62-2.04), respectively. This first meta-analysis of data from the current and published studies did not detect any association between the polymorphism of TNF 238 G/A and risk for T2D.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Genome-wide association study
Biology
Bioinformatics
Polymorphism, Single Nucleotide
White People
Endocrinology
Asian People
Polymorphism (computer science)
Internal medicine
Genotype
Internal Medicine
medicine
Humans
Aged
Tumor Necrosis Factor-alpha
Case-control study
General Medicine
Odds ratio
Publication bias
Middle Aged
Confidence interval
Diabetes Mellitus, Type 2
Case-Control Studies
Meta-analysis
Female
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14325233 and 09405429
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....cd2377c7ff1a2d5dd14bd6cdafebc730