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Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
- Source :
- Development. 126:3359-3370
- Publication Year :
- 1999
- Publisher :
- The Company of Biologists, 1999.
-
Abstract
- The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum). Within the telencephalon, the anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in Nkx2.1 function does not form pallidal structures, lacks basal forebrain TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex. We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage.
- Subjects :
- Male
Telencephalon
Ganglionic eminence
Thyroid Nuclear Factor 1
Striatum
Biology
Globus Pallidus
Mice
Cell Movement
Interneurons
Pregnancy
Basal ganglia
medicine
Animals
Hedgehog Proteins
Cholinergic neuron
Molecular Biology
Body Patterning
DNA Primers
Homeodomain Proteins
Mice, Knockout
Basal forebrain
Base Sequence
Cerebrum
DLX2
Genes, Homeobox
Gene Expression Regulation, Developmental
Nuclear Proteins
Proteins
Anatomy
Corpus Striatum
Mice, Mutant Strains
Cell biology
Phenotype
medicine.anatomical_structure
nervous system
Cerebral cortex
embryonic structures
Trans-Activators
Female
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 14779129 and 09501991
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....cd2274d97c33ddf2091c21ecb3af0bd8