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The prevalence of non-GII.4 norovirus genotypes in acute gastroenteritis outbreaks in Jinan, China
- Source :
- PLoS ONE, Vol 13, Iss 12, p e0209245 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Noroviruses (NoVs) are the leading cause of acute viral gastroenteritis outbreaks. From June 2015 to March 2017, fifteen outbreaks of acute gastroenteritis (AGE) were reported to the Jinan Center for Disease Control and Prevention in China. To identify the circulating NoV genotypes associated with outbreaks in Jinan, China, 414 specimens from the 15 outbreaks were collected and analyzed for the causative viruses, and phylogenetic analysis was performed on the NoV-positive strains. The NoV detection rate was 57.5% (238/414), and a total of 14 outbreaks were caused by NoVs (eight by infection with genogroup II (GII), five by mixed infection with GI and GII, and one by mixed infection with GII and rotavirus (RoV)-A). A total of 75 NoV sequences were obtained from 13 NoV-positive outbreaks and classified into seven genotypes (38 GII.17, 13 GII.2, 4 GII.3, 4 GII.1, 10 GI.6, 5 GI.5 and 1 GI.3), while GII.4 was not identified. The most prevalent genotype changed yearly during the 2015-2017 period. Phylogenetic analysis demonstrated that these NoV genotypes had high homology with the strains circulating worldwide, especially strains from Asian countries and cities. Our study illustrated that multiple non-GII.4 NoV genotypes were prevalent in outbreaks of AGE in Jinan, China. Year-round surveillance of multiple NoV genotypes could help health authorities reduce the impact of NoV outbreaks on public health.
- Subjects :
- 0301 basic medicine
Male
RNA viruses
Veterinary medicine
Viral Diseases
Epidemiology
viruses
medicine.disease_cause
Pathology and Laboratory Medicine
Disease Outbreaks
fluids and secretions
Rotavirus
Genotype
Prevalence
Medicine and Health Sciences
Child
Phylogeny
Caliciviridae Infections
Data Management
Multidisciplinary
Database and informatics methods
Sequence analysis
virus diseases
Phylogenetic Analysis
Middle Aged
Pollution
Gastroenteritis
Phylogenetics
Infectious Diseases
Medical Microbiology
Child, Preschool
Viral Pathogens
Epidemiological Monitoring
Viruses
Medicine
Female
Pathogens
Anatomy
High homology
Research Article
Adult
medicine.medical_specialty
China
Computer and Information Sciences
Adolescent
Bioinformatics
Science
Gastroenterology and Hepatology
Biology
Microbiology
Caliciviruses
Throat
03 medical and health sciences
Young Adult
stomatognathic system
medicine
Humans
Evolutionary Systematics
Microbial Pathogens
DNA sequence analysis
Taxonomy
Evolutionary Biology
Norovirus
Ecology and Environmental Sciences
Water Pollution
Organisms
Outbreak
Biology and Life Sciences
Calicivirus Infection
Acute gastroenteritis
Research and analysis methods
030104 developmental biology
Neck
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....cd1dbdfa727c0e51b9cca9b786963645