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Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition
- Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165:84-95
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- It is well established that risk for developing psychosis is largely mediated by the influence of genes, but identifying precisely which genes underlie that risk has been problematic. Focusing on endophenotypes, rather than illness risk, is one solution to this problem. Impaired cognition is a well-established endophenotype of psychosis. Here we aimed to characterize the genetic architecture of cognition using phenotypically detailed models as opposed to relying on general IQ or individual neuropsychological measures. In so doing we hoped to identify genes that mediate cognitive ability, which might also contribute to psychosis risk. Hierarchical factor models of genetically clustered cognitive traits were subjected to linkage analysis followed by QTL region-specific association analyses in a sample of 1,269 Mexican American individuals from extended pedigrees. We identified four genome wide significant QTLs, two for working and two for spatial memory, and a number of plausible and interesting candidate genes. The creation of detailed models of cognition seemingly enhanced the power to detect genetic effects on cognition and provided a number of possible candidate genes for psychosis.
- Subjects :
- Adult
Male
Risk
Candidate gene
Psychosis
Adolescent
Genotype
Quantitative Trait Loci
Cell Cycle Proteins
Genome-wide association study
Computational biology
Neuropsychological Tests
Quantitative trait locus
Article
Young Adult
Cellular and Molecular Neuroscience
Cognition
Mexican Americans
Basic Helix-Loop-Helix Transcription Factors
medicine
Humans
Genetics (clinical)
Aged
Aged, 80 and over
Genetics
Middle Aged
medicine.disease
Genetic architecture
Psychiatry and Mental health
Memory, Short-Term
Psychotic Disorders
Schizophrenia
Endophenotype
Female
Psychology
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15524841
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Accession number :
- edsair.doi.dedup.....cd1a0c3a27912227a00d42193530635c