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Urinary signature of anabolic steroids and glucocorticoids in humans by LC-MS
- Source :
- Talanta, Talanta, Elsevier, 2011, 83 (5), pp.1769-1773. ⟨10.1016/j.talanta.2010.10.030⟩
- Publication Year :
- 2010
-
Abstract
- International audience; A metabonomic strategy based on LC-MS was employed to investigate the metabolic profile of urine samples from 20 athletes who had been tested positive for corticoids and anabolic steroids and 29 controls. In this aim, different sample preparations and chromatographic conditions were compared. The acquired LC-MS data of doped athletes and controls were subjected to analysis of variance (ANOVA) and principal component analysis (PCA). Using this approach, molecular signature of human urine was obtained showing that metabonomics could be a complementary tool to discriminate different urinary profiles and to track down metabolic changes in humans.
- Subjects :
- medicine.medical_specialty
Anabolism
Doping products
Urinary system
Urine
01 natural sciences
Analytical Chemistry
03 medical and health sciences
Metabolomics
Anabolic Agents
Liquid chromatography–mass spectrometry
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Tandem Mass Spectrometry
Internal medicine
medicine
Corticoids
Metabolic profiling
Humans
Glucocorticoids
Anabolics
030304 developmental biology
0303 health sciences
Chromatography
Chemistry
010401 analytical chemistry
0104 chemical sciences
LC-MS
Endocrinology
Metabonomics
Steroids
Analysis of variance
Metabolic profile
Chromatography, Liquid
Subjects
Details
- ISSN :
- 18733573 and 00399140
- Volume :
- 83
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Talanta
- Accession number :
- edsair.doi.dedup.....cd14f1a7cfece4483b7ec2480bf0bc7f