Back to Search
Start Over
Irritable Bowel Syndrome–Type Symptoms in Patients With Inflammatory Bowel Disease: A Real Association or Reflection of Occult Inflammation?
- Source :
- American Journal of Gastroenterology. 105:1789-1794
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- Do gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) in apparent remission reflect the coexistence of irritable bowel syndrome (IBS) or subclinical inflammation? The aims of this study were as follows: (i) to prospectively determine the prevalence of IBS symptoms in IBD patients in remission; and (ii) to determine whether IBS symptoms correlate with levels of fecal calprotectin.Remission was defined by physician assessment: Crohn's disease (CD) activity indexor=150 and ulcerative colitis disease activity indexor=3, and serum C-reactive protein10, while off corticosteroids or biologics. Quality of life (QOL) (by inflammatory bowel disease questionnaire), the hospital anxiety and depression scale (HAD), and fecal calprotectin were measured.Rome II criteria for IBS were fulfilled in 37/62 (59.7%) of CD patients and by 17/44 (38.6%) of those with ulcerative colitis (UC). However, fecal calprotectin was significantly elevated above the upper limit of normal in both IBD patient groups, indicating the presence of occult inflammation. Furthermore, calprotectin levels were significantly higher in CD and UC patients with criteria for IBS than in those without IBS-type symptoms. QOL scores were lower and HAD scores higher among UC patients with IBS symptoms in comparison to those who did not have IBS symptoms.IBS-like symptoms are common in patients with IBD who are thought to be in clinical remission, but abnormal calprotectin levels suggest that the mechanism in most cases is likely to be occult inflammation rather than coexistent IBS.
- Subjects :
- Adult
Male
medicine.medical_specialty
610 Medicine & health
Inflammation
Gastroenterology
Inflammatory bowel disease
Statistics, Nonparametric
Diagnosis, Differential
Irritable Bowel Syndrome
Feces
Crohn Disease
10183 Swiss Institute of Allergy and Asthma Research
Surveys and Questionnaires
Internal medicine
Humans
Medicine
2715 Gastroenterology
In patient
Colitis
Irritable bowel syndrome
Chi-Square Distribution
Hepatology
business.industry
digestive, oral, and skin physiology
Case-control study
medicine.disease
Occult
digestive system diseases
Case-Control Studies
2721 Hepatology
Colitis, Ulcerative
Female
medicine.symptom
business
Leukocyte L1 Antigen Complex
Irritable bowel
Biomarkers
Subjects
Details
- ISSN :
- 00029270
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- American Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....cd13f3c7fae612cc3634919c3be72684