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Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes
- Source :
- ResearcherID, Digital.CSIC. Repositorio Institucional del CSIC, instname, Scopus-Elsevier, idUS. Depósito de Investigación de la Universidad de Sevilla, Europe PubMed Central
- Publication Year :
- 1999
- Publisher :
- American Society for Microbiology, 1999.
-
Abstract
- We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.
- Subjects :
- Klebsiella pneumoniae
Porins
Drug resistance
Biology
medicine.disease_cause
Microbiology
Cefoxitin
Bacterial Proteins
Mechanisms of Resistance
medicine
Humans
Pharmacology (medical)
Insertion
Insertion sequence
Cephamycins
Antibacterial agent
Pharmacology
Mutation
Drug Resistance, Microbial
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Mutagenesis, Insertional
Infectious Diseases
Porin
DNA Transposable Elements
bacteria
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....cd11bc9fb4796916384e999276120088
- Full Text :
- https://doi.org/10.1128/aac.43.4.937